You need to check with the vendor but it is possible using an SQL query and I have posted a solution else where in this forum. You cannot search the tables for a resource name as they encrypt it. But if you have other criteria you can use, like the DNS Name or the IP address, then you can construct a query to update multiple row.
first construct a query to display the rows you are interested in, e.g.
Select * from [PassTrix] . [dbo] . [Ptrx_Resource] where RESOURCEDESC like '%Resource imported from domain : %' and IPADDRESS like 'LON%'
If this shows what you need then you can update like this
UPDATE [PassTrix] . [dbo] . [Ptrx_Resource]
SET [LOCATION] = 'London'
, [RESOURCEDESC] = 'London Workstation'
-- ,[PORT]=3389
-- ,[SSHPORT]=22
-- ,DOMAINNAME='MYDOMAINNAME'
DEPARTMENT = 'Service Desk'
where RESOURCEDESC like '%Resource imported from domain : %' and IPADDRESS like 'LON%'
NOTE: MAKE A BACKUP BEFORE DOING THIS!